2,8-Diazaspiro[4.5]decan-1-one

2,8-Diazaspiro[4.5]decan-1-one - Names and Identifiers

Name	2,8-diazaspiro[4.5]decan-1-one
Synonyms	8-Diazaspiro[4.5]decan-1-one 2,8-Diazaspiro[4.5]decan-1-one 2,8-diazaspiro[4.5]decan-1-one 1-Oxo-2,8-diazaspiro[4.5]decane 2,8-diaza-spiro[4,5]decan-1-one 2,8-Diazaspiro[4.5]decan-1-one HCL Salt 2,8-diazaspiro[4.5]decan-1-one (HCL form)
CAS	546086-95-7
EINECS	604-604-1
InChI	InChI=1/C8H14N2O/c11-7-8(3-6-10-7)1-4-9-5-2-8/h9H,1-6H2,(H,10,11)

2,8-Diazaspiro[4.5]decan-1-one - Physico-chemical Properties

Molecular Formula	C8H14N2O
Molar Mass	154.21
Density	1.12
Boling Point	360℃
Flash Point	171℃
Vapor Presure	0mmHg at 25°C
pKa	16.07±0.20(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.533

2,8-Diazaspiro[4.5]decan-1-one - Introduction

2,8-diazaspiro[4.5]decan-1-one(2,8-diazaspiro[4.5]decan-1-one) is a nitrogen-containing organic compound. The following is a description of the properties, uses, preparation and safety information of this compound:

Nature:
-Appearance: Colorless to pale yellow solid.
-Solubility: 2,8-diazaspiro[4.5]decan-1-one is insoluble in water and soluble in organic solvents such as methanol, ethanol and dimethylformamide.
-Melting point: about 130-132°C.
-Stability: relatively stable at room temperature, but avoid exposure to strong light and oxygen.

Use:
- 2,8-diazaspiro[4.5]decan-1-one is commonly used as an intermediate in organic synthesis for the synthesis of other nitrogen-containing compounds.
-It can also be used in drug synthesis or as a chemical reagent.

Preparation Method:
2,8-diazaspiro[4.5]decan-1-one can be synthesized by the following steps:
1. dimethyl adipate reacts with malononitrile to generate 2,5-dicyano -1,4-hexanedione.
2. react 2,5-dicyano -1,4-hexanedione with thizone to generate 2,8-diazaspiro[4.5]decan-1-one.

Safety Information:
Specific safety information on the decan-1-one of 2,8-diazaspiro[4.5] is currently lacking. However, as an organic compound, it should be used in accordance with general laboratory safety practices, including wearing appropriate protective equipment (such as gloves, goggles and laboratory coats) to avoid inhalation, ingestion or contact with skin.

Last Update：2024-04-09 20:45:29